Chapter 2. What is a Stem Cell?
- Gregory Bock Organizer,
- Jamie Goode
Published Online: 7 OCT 2008
DOI: 10.1002/0470091452.ch2
Copyright © Novartis Foundation 2005
Book Title
Stem Cells: Nuclear Reprogramming and Therapeutic Applications: Novartis Foundation Symposium 265
Additional Information
How to Cite
Solter, D. (2008) What is a Stem Cell?, in Stem Cells: Nuclear Reprogramming and Therapeutic Applications: Novartis Foundation Symposium 265 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470091452.ch2
Publication History
- Published Online: 7 OCT 2008
- Published Print: 18 MAR 2005
ISBN Information
Print ISBN: 9780470091432
Online ISBN: 9780470091456
- Summary
- Chapter
Keywords:
- human embryonic stem (ES) cell;
- human fibroblastic feeder;
- ES cell derivatives;
- human ES cell lines;
- leukaemia inhibitory factor (LIF);
- bone morphogenetic protein 4 (BMP4);
- POU5F1;
- ‘therapeutic cloning’;
- embryonic germ (EG) cells;
- developmental plasticity of adult stem cells
Summary
The nature, origin, sources and possible modes of derivation of human embryonic stem cells are scrutinized. Can cells, with a capacity for differentiation equal to that of embryonic stem cells, be derived from adult organisms and what are the appropriate sources for such cells? Do stem cells found in adult organs and tissues possess developmental plasticity, i.e. are they able to transdifferentiate across germ layer boundaries? What are the anticipated short- and long-term uses of embryonic and adult stem cells? The current state of science and contentious issues as related to these questions are discussed.