Chapter 3. Bone Marrow-Derived Hepatocytes
- Gregory Bock Organizer,
- Jamie Goode
Published Online: 7 OCT 2008
DOI: 10.1002/0470091452.ch3
Copyright © Novartis Foundation 2005
Book Title
Stem Cells: Nuclear Reprogramming and Therapeutic Applications: Novartis Foundation Symposium 265
Additional Information
How to Cite
Grompe, M. (2008) Bone Marrow-Derived Hepatocytes, in Stem Cells: Nuclear Reprogramming and Therapeutic Applications: Novartis Foundation Symposium 265 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470091452.ch3
Publication History
- Published Online: 7 OCT 2008
- Published Print: 18 MAR 2005
ISBN Information
Print ISBN: 9780470091432
Online ISBN: 9780470091456
- Summary
- Chapter
Keywords:
- bone marrow-derived hepatocyte;
- bone marrow resident stem cells;
- haematopoietic system;
- hepatic oval cells;
- bone marrow transplantation (BMT) patients;
- fluorescent in situ hybridization (FISH);
- haematopoietic stem cell (HSC) and KLTS cell;
- granulocyte/macrophage progenitors (GMPs);
- specialized endodermal stem cell;
- cell fusion
Summary
Several independent reports have demonstrated that bone marrow cells can give rise to different hepatic epithelial cells types, including oval cells, hepatocytes and duct epithelium. These observations have resulted in the hypothesis that bone marrow resident stem cells, specifically haematopoietic stem cells, are an important source for liver epithelial cell replacement, particularly during chronic injury. However, the bulk of published data on the role of bone marrow stem cells in liver damage suggest that they do not play a significant physiological role in replacement of epithelial cells in any known form of hepatic injury. Fully functional bone marrow-derived hepatocytes indeed exist, but are extremely rare and are generated by cell fusion, not stem cell differentiation.