Chapter 15. Prospects for Gene Therapy of HIV Infections and AIDS

  1. Anthony Meager
  1. Caroline G.L. Lee1,
  2. Michael M. Gottesman1,
  3. Kuan-Teh Jeang2

Published Online: 10 DEC 2001

DOI: 10.1002/0470842385.ch15

Book Title

Gene Therapy Technologies, Applications and Regulations: From Laboratory to Clinic

Gene Therapy Technologies, Applications and Regulations: From Laboratory to Clinic

Additional Information

How to Cite

Lee, C. G.L., Gottesman, M. M. and Jeang, K.-T. (2001) Prospects for Gene Therapy of HIV Infections and AIDS, in Gene Therapy Technologies, Applications and Regulations: From Laboratory to Clinic (ed A. Meager), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470842385.ch15

Editor Information

  1. Division of Immunobiology, The National Institute for Biological Standards and Control, South Mimms, UK

Author Information

  1. 1

    Laboratory of Cell Biology, National Cancer Institute, National Inst. of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

  2. 2

    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

Publication History

  1. Published Online: 10 DEC 2001
  2. Published Print: 17 SEP 1999

ISBN Information

Print ISBN: 9780471967095

Online ISBN: 9780470842386

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Keywords:

  • human immunodeficiency virus;
  • dominant-negative protein;
  • antisense RNA;
  • apoptosis;
  • vaccine;
  • antibody;
  • immune response;
  • self-inactivating vector;
  • gold particles;
  • cationic liposomes

Summary

Current drug treatments for human immunodeficiency virus (HIV) infection are not ideal therefore gene therapy deserves consideration. HIV is a lentivirus that binds to receptors on T lymphocytes or macrophages with the help of specific co-receptors. Therapies may interfere with this binding or perturb viral replication and assembly within the cell, using dominant-negative proteins or antisense RNAs. Induction of apoptosis is another strategy but the global solution to AIDS requires the development of an effective vaccine. Genetic manipulation can create live attenuated virus but there are fears about reversion to virulence. Alternatives include the intracellular expression of antibodies against HIV proteins and augmentation of the immune system, e.g. by designing interferons that are induced by HIV proteins. Gene delivery may occur via viral vectors, including self-inactivating vectors that obviate the fear of insertional mutagenesis, adenovirus and herpes simplex virus, or by DNA-coated gold particles or cationic liposomes.

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