Standard Article

N,N-Diethyl-α,α-difluoro-3-methylbenzylamine

  1. Shoji Hara

Published Online: 16 SEP 2013

DOI: 10.1002/047084289X.rn01633

e-EROS Encyclopedia of Reagents for Organic Synthesis

e-EROS Encyclopedia of Reagents for Organic Synthesis

How to Cite

Hara, S. 2013. N,N-Diethyl-α,α-difluoro-3-methylbenzylamine. e-EROS Encyclopedia of Reagents for Organic Synthesis. .

Author Information

  1. Hokkaido University, Sapporo, Japan

Publication History

  1. Published Online: 16 SEP 2013

Chemistry Terms

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Abstract

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[500131-50-0] C12H17F2N (MW 213.27)

(reagent used for the conversion of primary, secondary, and benzylic alcohols to the corresponding fluorides, 1,2- and 1,3-diols to acylated fluorohydrins or monoacylated diols, aldehydes to gem-difluorides, epoxides to vic-difluorides, β-diketones to β-fluoro-α,β-unsaturated ketones, and diethanolamine to cyclic amide acetal)

Alternative Name: DFMBA.

Physical Data: bp 81–83 °C/4 mmHg; d = 1.03 g cm−3 at 25 °C; stable up to 180 °C and decomposes gradually at 210 °C.

Solubility: well soluble in CH2Cl2, toluene, and Et2O; slightly soluble in hexane.

Form Supplied in: colorless liquid, commercially available.

Analysis of Reagent Purity: 1H NMR.

Purification: distillation under N2.

Handling, Storage, and Precautions: decomposes gradually by moisture in air; therefore, operations should be carried out under minimum contact to moisture. Glassware can be used, but the use of Teflon™ vessels is recommended. Can be stored in the refrigerator under inert atmosphere.

Featured Compounds

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  1. 1 - 47
Compound Information
Molecular Weight:213.2669
Molecular Formula:C12H17F2N
InChIKey:SGDDSVYULWVCQK-UHFFFAOYSA-N
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Compound Information
Molecular Weight:170.2918
Molecular Formula:C11H22O
InChIKey:GIEMHYCMBGELGY-UHFFFAOYSA-N
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Compound Information
Molecular Weight:172.2828
Molecular Formula:C11H21F
InChIKey:QZILBBQFSMKDBU-UHFFFAOYSA-N
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Compound Information
Molecular Weight:100.2019
Molecular Formula:C7H16
InChIKey:IMNFDUFMRHMDMM-UHFFFAOYSA-N
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Compound Information
Molecular Weight:186.3342
Molecular Formula:C12H26O
InChIKey:XSWSEQPWKOWORN-UHFFFAOYSA-N
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Compound Information
Molecular Weight:188.3253
Molecular Formula:C12H25F
InChIKey:FBCUDWSGTMPPHC-UHFFFAOYSA-N
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Compound Information
Molecular Weight:170.3348
Molecular Formula:C12H26
InChIKey:SNRUBQQJIBEYMU-UHFFFAOYSA-N
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Compound Information
Molecular Weight:187.034
Molecular Formula:C7H7BrO
InChIKey:VEDDBHYQWFOITD-UHFFFAOYSA-N
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Compound Information
Molecular Weight:189.025
Molecular Formula:C7H6BrF
InChIKey:LFTYKVGDROWKQC-UHFFFAOYSA-N
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Compound Information
Molecular Weight:348.3026
Molecular Formula:C14H20O10
InChIKey:FEQXFAYSNRWXDW-RGDJUOJXSA-N
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Compound Information
Molecular Weight:350.2937
Molecular Formula:C14H19FO9
InChIKey:NGYYXVXMDLMRLI-RGDJUOJXSA-N
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Compound Information
Molecular Weight:88.1051
Molecular Formula:C4H8O2
InChIKey:RYHBNJHYFVUHQT-UHFFFAOYSA-N
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Compound Information
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound Information
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound Information
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound Information
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound Information
Molecular Weight:161.189
Molecular Formula:C4H10F3NS
InChIKey:CSJLBAMHHLJAAS-UHFFFAOYSA-N
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Compound Information
Molecular Weight:104.1476
Molecular Formula:C5H12O2
InChIKey:GTCCGKPBSJZVRZ-WHFBIAKZSA-N
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Compound Information
Molecular Weight:224.2713
Molecular Formula:C13H17FO2
InChIKey:FWRDWLKFFIFRIA-MNOVXSKESA-N
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Compound Information
Molecular Weight:134.1736
Molecular Formula:C6H14O3
InChIKey:SBZXBUIDTXKZTM-UHFFFAOYSA-N
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Compound Information
Molecular Weight:280.3163
Molecular Formula:C15H20O5
InChIKey:GRXHNZOXJNIXKZ-CFYKVZDHSA-N
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Compound Information
Molecular Weight:400.44
Molecular Formula:C23H25FO5
InChIKey:MAXOMXKHWIUDEV-NOBHMXGUSA-N
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Compound Information
Molecular Weight:270.2536
Molecular Formula:C13H15FO5
InChIKey:JPGVEKIZAOFUHW-NOOOWODRSA-N
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Compound Information
Molecular Weight:166.1739
Molecular Formula:C9H10O3
InChIKey:WJUFSDZVCOTFON-UHFFFAOYSA-N
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Compound Information
Molecular Weight:188.1713
Molecular Formula:C9H10F2O2
InChIKey:FTBTWXUOHJOJEG-UHFFFAOYSA-N
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Compound Information
Molecular Weight:161.209
Molecular Formula:C6H18F3N
InChIKey:IKGLACJFEHSFNN-UHFFFAOYSA-N
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Compound Information
Molecular Weight:170.2918
Molecular Formula:C11H22O
InChIKey:KMPQYAYAQWNLME-UHFFFAOYSA-N
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Compound Information
Molecular Weight:192.2892
Molecular Formula:C11H22F2
InChIKey:JTSRDHRHXOTRPC-UHFFFAOYSA-N
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Compound Information
Molecular Weight:210.228
Molecular Formula:C14H10O2
InChIKey:MLZBRARCTFICSV-UHFFFAOYSA-N
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Compound Information
Molecular Weight:232.2254
Molecular Formula:C14H10F2O
InChIKey:DKLQLRPOBKIYFA-UHFFFAOYSA-N
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Compound Information
Molecular Weight:254.2228
Molecular Formula:C14H10F4
InChIKey:YWMFRBTUNOYOKS-UHFFFAOYSA-N
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Compound Information
Molecular Weight:228.3279
Molecular Formula:C13H24O3
InChIKey:VKMUVHUFUIYSMS-UHFFFAOYSA-N
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Compound Information
Molecular Weight:250.3253
Molecular Formula:C13H24F2O2
InChIKey:MUQNIWRXMDCTCD-UHFFFAOYSA-N
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Compound Information
Molecular Weight:162.1852
Molecular Formula:C10H10O2
InChIKey:CVBUKMMMRLOKQR-UHFFFAOYSA-N
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Compound Information
Molecular Weight:164.1763
Molecular Formula:C10H9FO
InChIKey:AFNRWGZBZKNNAY-FPLPWBNLSA-N
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Compound Information
Molecular Weight:204.2649
Molecular Formula:C13H16O2
InChIKey:HORVLKADAZQYRS-UHFFFAOYSA-N
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Compound Information
Molecular Weight:206.256
Molecular Formula:C13H15FO
InChIKey:RFANGRRPHMSMQD-XFXZXTDPSA-N
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Compound Information
Molecular Weight:216.1566
Molecular Formula:C10H7F3O2
InChIKey:VVXLFFIFNVKFBD-UHFFFAOYSA-N
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Compound Information
Molecular Weight:218.1477
Molecular Formula:C10H6F4O
InChIKey:JJMMYOZRXWAKMW-TWGQIWQCSA-N
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Compound Information
Molecular Weight:206.1187
Molecular Formula:C8H5F3O3
InChIKey:OWLPCALGCHDBCN-UHFFFAOYSA-N
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Compound Information
Molecular Weight:208.1098
Molecular Formula:C8H4F4O2
InChIKey:UMZLKNFFHYJPNZ-DAXSKMNVSA-N
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Compound Information
Molecular Weight:102.1317
Molecular Formula:C5H10O2
InChIKey:VCVOSERVUCJNPR-SYDPRGILSA-N
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Compound Information
Molecular Weight:220.2643
Molecular Formula:C13H16O3
InChIKey:QQZABCYGKLDGFV-NWDGAFQWSA-N
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Compound Information
Molecular Weight:338.397
Molecular Formula:C21H22O4
InChIKey:UGAXLEUTHJMBOH-KDURUIRLSA-N
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Compound Information
Molecular Weight:84.933
Molecular Formula:CH2Cl2
InChIKey:YMWUJEATGCHHMB-UHFFFAOYSA-N
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Compound Information
Molecular Weight:105.1356
Molecular Formula:C4H11NO2
InChIKey:Not Available
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Compound Information
Molecular Weight:205.253
Molecular Formula:C12H15NO2
InChIKey:QHXYWWBWQOPXAA-UHFFFAOYSA-N
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