Chapter 17. Strategies for Quantifying Pet Imaging Data from Tracer Studies of Brain Receptors and Enzymes

  1. Michael J. Welch1 and
  2. Carol S. Redvanly2
  1. Jean Logan

Published Online: 28 JAN 2005

DOI: 10.1002/0470846380.ch17

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

How to Cite

Logan, J. (2002) Strategies for Quantifying Pet Imaging Data from Tracer Studies of Brain Receptors and Enzymes, in Handbook of Radiopharmaceuticals: Radiochemistry and Applications (eds M. J. Welch and C. S. Redvanly), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846380.ch17

Editor Information

  1. 1

    Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway Boulevard, Campus Box 8225, St. Louis, MO, USA

  2. 2

    Department of Chemistry, Brookhaven National Laboratory Associated Universities Ltd, Upton, New York, USA

Author Information

  1. Department of Chemistry, Brookhaven National Laboratory Associated Universities Ltd, Upton, New York, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 27 NOV 2002

ISBN Information

Print ISBN: 9780471495604

Online ISBN: 9780470846384

SEARCH

Keywords:

  • positron-emission tomography (PET);
  • single photon emission computed tomography (SPECT);
  • quantifying PET imaging data

Summary

This chapter contains sections titled:

  • Introduction

  • Models

  • Strategies for Determining Model Parameters

  • Modeling Options for Reversible Ligands

  • Modeling Options for Irreversible Ligands

  • Without Plasma Input

  • Limitations, Reliability and Other Factors Related to Modeling Image Data

  • Reference Tissue Methods

  • Bias in the Graphical Analysis Method

  • Construction of Parametric Images

  • Summary

  • Acknowledgments

  • References