Chapter 19. Pet Imaging Studies in Drug Abuse Research

  1. Michael J. Welch2 and
  2. Carol S. Redvanly3
  1. Joanna S. Fowler3,
  2. Nora D. Volkow1,
  3. Yu-Shin Ding1,
  4. Jean Logan3 and
  5. Gene-Jack Wang1

Published Online: 28 JAN 2005

DOI: 10.1002/0470846380.ch19

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

How to Cite

Fowler, J. S., Volkow, N. D., Ding, Y.-S., Logan, J. and Wang, G.-J. (2002) Pet Imaging Studies in Drug Abuse Research, in Handbook of Radiopharmaceuticals: Radiochemistry and Applications (eds M. J. Welch and C. S. Redvanly), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846380.ch19

Editor Information

  1. 2

    Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway Boulevard, Campus Box 8225, St. Louis, MO, USA

  2. 3

    Department of Chemistry, Brookhaven National Laboratory Associated Universities Ltd, Upton, New York, USA

Author Information

  1. 1

    Brookhaven National Laboratory, Upton, NY, USA

  2. 3

    Department of Chemistry, Brookhaven National Laboratory Associated Universities Ltd, Upton, New York, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 27 NOV 2002

ISBN Information

Print ISBN: 9780471495604

Online ISBN: 9780470846384

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Keywords:

  • labeled precursors;
  • brain pharmokinetics;
  • PET imaging

Summary

This chapter contains sections titled:

  • Introduction

  • The Importance of Chemistry

  • Labeled Precursors

  • Tracer Kinetics

  • Mechanistic Studies

  • Pet Studies of Psychostimulants

  • Brain Pharmacokinetics

  • Distribution and Kinetics in Peripheral Organs

  • Comparative Studies of Cocaine and Methylphenidate (Ritalin)

  • Pharmacokinetics

  • Dopamine Transporter Occupancy

  • Imaging the Cocaine Abuser's Brain

  • Imaging the Smoker's Brain

  • Vulnerability

  • Summary

  • Acknowledgment

  • References