Chapter 5. Aspects on the Synthesis of 11C-Labelled Compounds

  1. Michael J. Welch3 and
  2. Carol S. Redvanly4
  1. Gunnar Antoni1,
  2. Tor Kihlberg2 and
  3. Bengt Långström2

Published Online: 28 JAN 2005

DOI: 10.1002/0470846380.ch5

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

Handbook of Radiopharmaceuticals: Radiochemistry and Applications

How to Cite

Antoni, G., Kihlberg, T. and Långström, B. (2002) Aspects on the Synthesis of 11C-Labelled Compounds, in Handbook of Radiopharmaceuticals: Radiochemistry and Applications (eds M. J. Welch and C. S. Redvanly), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846380.ch5

Editor Information

  1. 3

    Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway Boulevard, Campus Box 8225, St. Louis, MO, USA

  2. 4

    Department of Chemistry, Brookhaven National Laboratory Associated Universities Ltd, Upton, New York, USA

Author Information

  1. 1

    Uppsala University PET Centre, Uppsala University S-751 85 Uppsala, Sweden

  2. 2

    Uppsala University PET Centre; Institute of Chemistry, Uppsala University S-751 85 Uppsala, Sweden

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 27 NOV 2002

ISBN Information

Print ISBN: 9780471495604

Online ISBN: 9780470846384

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Keywords:

  • c-labelled compounds;
  • positron-emission tomography (PET);
  • PET-camera technology

Summary

This chapter contains sections titled:

  • Introduction

  • Labelling Strategies

  • Biological Perspectives

  • Methods for 11C-syntheses

  • Enzyme in Labelling Synthesis

  • Transition Metal Mediated Reactions

  • Ring-closures

  • The Synthesis of Radiotracers for PET

  • Synthesis of Compounds for the Study of Receptors and Enzymes

  • Synthesis of 11C-labelled Endogenous Compounds

  • Miscellaneous 11C-compounds

  • Conclusions – Future Perspectives

  • References