Chapter 2. Natural Course of Diabetic Nephropathy
- Christoph Hasslacher
Published Online: 28 DEC 2001
DOI: 10.1002/0470846445.ch2
Copyright © 2001 John Wiley & Sons, Ltd
Book Title
Diabetic Nephropathy
Additional Information
How to Cite
Hasslacher, C. (2001) Natural Course of Diabetic Nephropathy, in Diabetic Nephropathy (ed C. Hasslacher), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846445.ch2
Editor Information
St Josefskrankenhaus, Heidelberg, Germany
Publication History
- Published Online: 28 DEC 2001
- Published Print: 25 OCT 2001
Book Series:
ISBN Information
Print ISBN: 9780471489924
Online ISBN: 9780470846445
- Summary
- Chapter
Keywords:
- natural course;
- stages of nephropathy;
- microalbuminuria;
- macroalbuminuria;
- renal failure;
- susceptibility to nephropathy;
- progression factors
Summary
The natural progression of diabetic nephropathy is essentially characterised by a rise of albumin excretion in the urine, a decrease of glomerular filtration rate and an increase in blood pressure. As a rule, terminal renal failure takes years to develop and is classified in five stages depending on the clinical and functional changes. The risk of nephropathy is similar in patients with type 1 and type 2 diabetes: 30% to 50% develop an advanced stage of nephropathy. The propensity to develop nephropathy differs in the population groups and therefore also appears to be genetically determined. The progression of nephropathy development is influenced by numerous factors that can be modified by therapeutic intervention: control of blood sugar and blood pressure, smoking, protein intake, hyperlipidemia and proteinuria.