Viruses Causing Diarrhoea in AIDS

  1. Derek Chadwick and
  2. Jamie A. Goode
  1. Richard C. G. Pollok

Published Online: 7 OCT 2008

DOI: 10.1002/0470846534.ch17

Gastroenteritis Viruses: Novartis Foundation Symposium 238

Gastroenteritis Viruses: Novartis Foundation Symposium 238

How to Cite

Pollok, R. C. G. (2001) Viruses Causing Diarrhoea in AIDS, in Gastroenteritis Viruses: Novartis Foundation Symposium 238 (eds D. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846534.ch17

Author Information

  1. Digestive Disease Research Centre, St Bartholomew's & The Royal London School of Medicine and Dentistry, London, UK

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 16 MAY 2001

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471496632

Online ISBN: 9780470846537

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Keywords:

  • virus;
  • diarrhoea;
  • gastroenteritis;
  • AIDS;
  • HIV;
  • cytomegalovirus;
  • CMV;
  • HAART;
  • gastrointestinal tract;
  • infection;
  • adenovirus

Summary

Opportunistic viral enteritis is an important gastrointestinal manifestation of HIV related disease. Cytomegalovirus (CMV) is a well established aetiological agent of disease in the gastrointestinal tract in this group. CMV enteritis may affect any region of the bowel, most commonly the colon. Diagnosis and management of these infections may be difficult. The role of other viruses in so-called ‘pathogen-negative’ diarrhoea remains controversial. The clinical importance of HIV-specific enteropathy is probably limited. Several viruses including astrovirus, picobirnavirus, small round structured virus and rotavirus have been implicated HIV-related diarrhoea. In addition, adenovirus has been linked to persistent diarrhoea in patients with a characteristic adenovirus colitis. The spectrum of disease morbidity and mortality amongst HIV patients has altered dramatically since the wide spread use of highly active antiretroviral therapy (HAART). Opportunistic infections, including CMV infection of the gastrointestinal tract in patients with AIDS, have diminished greatly. AIDS patients with CMV are able successfully to discontinue anti-CMV treatment without disease reactivation and with a parallel reduction in CMV viraemia following the initiation of HAART.