Correlates of Protection Against Rotavirus Infection and Disease

  1. Derek Chadwick and
  2. Jamie A. Goode
  1. Paul A. Offit

Published Online: 7 OCT 2008

DOI: 10.1002/0470846534.ch8

Gastroenteritis Viruses: Novartis Foundation Symposium 238

Gastroenteritis Viruses: Novartis Foundation Symposium 238

How to Cite

Offit, P. A. (2001) Correlates of Protection Against Rotavirus Infection and Disease, in Gastroenteritis Viruses: Novartis Foundation Symposium 238 (eds D. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846534.ch8

Author Information

  1. The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA and The Wistar Institute of Anatomy and Biology, Philadelphia, PA, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 16 MAY 2001

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471496632

Online ISBN: 9780470846537

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Keywords:

  • rotavirus;
  • children;
  • infection;
  • pathogenesis;
  • protection;
  • infants;
  • diarrhoea;
  • IgA;
  • mucosal surface;
  • RSV;
  • T lymphocytes;
  • B cells;
  • vaccine;
  • gastroenteritis

Summary

Repeated infections with the ‘mucosal’ pathogen rotavirus are common in children. Subsequent rotavirus infections usually cause milder symptoms than first-time infections. Therefore, although natural rotavirus infection attenuates the severity of subsequent infections, it does not prevent reinfection or mild disease. On the other hand, natural infection with ‘systemic’ viruses such as measles, mumps, rubella, or varicella often confers life-long protection against mild disease associated with reinfection. The degree to which differences in the pathogenesis of systemic and mucosal pathogens determines differences in the capacity of natural infection to induce life-long protective immunity will be discussed. This paradigm will be used to explore the immunological effector functions associated with protection against rotavirus challenge.