Chapter 6. Prevention of Type 2 Diabetes

  1. R. Williams2,
  2. W. Herman3,
  3. A.-L. Kinmonth5 and
  4. N. J. Wareham4
  1. Richard F. Hamman

Published Online: 9 APR 2003

DOI: 10.1002/0470846585.ch6

The Evidence Base for Diabetes Care

The Evidence Base for Diabetes Care

How to Cite

Hamman, R. F. (2002) Prevention of Type 2 Diabetes, in The Evidence Base for Diabetes Care (eds R. Williams, W. Herman, A.-L. Kinmonth and N. J. Wareham), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846585.ch6

Editor Information

  1. 2

    Nuffield Institute for Health, University of Leeds, 71-75 Clarendon Road, Leeds LS2 9PL, UK

  2. 3

    Department of Internal Medicine and Epidemiology, 1500 East Medical Center Drive, 3920 Taubman Center, Box 0345, Ann Arbor, MI 48109, USA

  3. 4

    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK

  4. 5

    General Practice and Primary Care Research Unit, Dept. of Public Health & Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK

Author Information

  1. Department of Preventive Medicine and Biometrics, Box B-119, 4200 East Ninth Avenue, Denver, CO 80262, USA

Publication History

  1. Published Online: 9 APR 2003
  2. Published Print: 27 AUG 2002

ISBN Information

Print ISBN: 9780471988762

Online ISBN: 9780470846582

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Keywords:

  • lifestyle;
  • randomized controlled trial;
  • physical activity;
  • diet;
  • sulfonylurea;
  • biguanide;
  • thiazolidinedione;
  • alpha-glucosidase inhibitor;
  • angiotensin converting enzyme inhibitor

Summary

Recent trials have confirmed obesity as a risk factor for type 2 diabetes and shown that interventions aimed at reversing the steps leading to the disease can succeed in optimal circumstances. Most of the work reviewed here focuses on interventions aimed at individuals, to alter lifestyle and to reduce the metabolic derangements known to be part of the pathways to disease. Less work has been done on broader social and psychological determinants, yet successful primary prevention may require a combination approach. Prevention requires a knowledge of the natural history of diabetes, effective and simple screening tests, and effective interventions. This chapter summarizes the available clinical trials and observational studies that address whether there are efficacious and effective interventions to prevent or delay the onset of type 2 diabetes.