Chapter 14. Human Genetics and Genetic Enhancement

  1. John Bryant Professor2,
  2. Dr Linda Baggott la Velle3,
  3. Revd Dr John Searle4
  1. Peter Turnpenny1,
  2. John Bryant2

Published Online: 18 APR 2002

DOI: 10.1002/0470846593.ch14

Bioethics for Scientists

Bioethics for Scientists

How to Cite

Turnpenny, P. and Bryant, J. (2002) Human Genetics and Genetic Enhancement, in Bioethics for Scientists (eds J. Bryant, L. B. la Velle and J. Searle), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846593.ch14

Editor Information

  1. 2

    School of Biological Sciences, University of Exeter, Exeter, UK

  2. 3

    Graduate School of Education, University of Bristol, Bristol, UK

  3. 4

    Exeter & District Hospice, Exeter, UK

Author Information

  1. 1

    Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, EX2 5DW, UK

  2. 2

    School of Biological Sciences, University of Exeter, Exeter, UK

Publication History

  1. Published Online: 18 APR 2002
  2. Published Print: 31 MAR 2002

ISBN Information

Print ISBN: 9780471495321

Online ISBN: 9780470846599

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Keywords:

  • eugenics;
  • fetus/foetus;
  • gene therapy;
  • genetic diagnosis;
  • genetic disease;
  • genetic enhancement;
  • GM;
  • human genome;
  • mammal;
  • transgenic

Summary

Advances in human genetics have opened new possibilities in the detection and treatment of genetic disease. It is possible to diagnose genetic disease/malfunction at all stages of life, including pre-implantation embryos, fetuses in established pregnancies and fully-formed live humans. This provides information that enables prospective parents to make decisions about the birth of babies with genetic disease/malfunction or even to select embryos with particular desirable characteristics. Meanwhile, GM techniques facilitate gene therapy to replace ‘faulty’ genes. This is currently only permitted with somatic cells but germ-line gene therapy is likely not to be long-delayed. However, the distinction between GM for therapy and GM for enhancement is not very clear either practically or ethically. Indeed, many of these developments raise ethical concerns, including the possible devaluation of the genetically ‘disabled’ and the possibility of a ‘new eugenics’ based on eliminating what is perceived as genetic disease, combined with the availability of genetic enhancement.