The Contribution of the Ganglionic Eminence to the Neuronal Cell Types of the Cerebral Cortex

  1. Gregory R. Bock and
  2. Gail Cardew
  1. J. G. Parnavelas1,
  2. S. A. Anderson2,
  3. A. A. Lavdas1,
  4. M. Grigoriou1,
  5. V. Pachnis1 and
  6. J. L. R. Rubenstein2

Published Online: 29 APR 2008

DOI: 10.1002/0470846631.ch10

Evolutionary Developmental Biology of the Cerebral Cortex: Novartis Foundation Symposium 228

Evolutionary Developmental Biology of the Cerebral Cortex: Novartis Foundation Symposium 228

How to Cite

Parnavelas, J. G., Anderson, S. A., Lavdas, A. A., Grigoriou, M., Pachnis, V. and Rubenstein, J. L. R. (2000) The Contribution of the Ganglionic Eminence to the Neuronal Cell Types of the Cerebral Cortex, in Evolutionary Developmental Biology of the Cerebral Cortex: Novartis Foundation Symposium 228 (eds G. R. Bock and G. Cardew), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470846631.ch10

Author Information

  1. 1

    Department of Anatomy and Developmental Biology, University College London, London, UK

  2. 2

    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, USA

Publication History

  1. Published Online: 29 APR 2008
  2. Published Print: 22 MAY 2000

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471979784

Online ISBN: 9780470846636

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Keywords:

  • cerebral cortex;
  • neurons;
  • pyramidal cells;
  • interneurons;
  • ganglionic eminence;
  • GABA;
  • LGE;
  • MGE;
  • Dlx2

Summary

The principal neuronal types of the mammalian cerebral cortex are the excitatory pyramidal cells and the inhibitory interneurons, the non-pyramidal cells. It is thought that these neurons arise in the ventricular zone surrounding the telencephalic ventricles. From there, newly generated neurons migrate outward along the processes of radial glial cells to reach the cortical plate where they accumulate in an ‘inside-out’ sequence to form the six-layered structure of the neocortex. Here we review emerging evidence that pyramidal neurons are generated in the cortical ventricular zone, whereas the majority of the non-pyramidal cells arise in the ganglionic eminences of the ventral telencephalon. These neurons follow tangential migratory routes to reach their positions in the developing cortex.