Relationship Between the Sarcoplasmic Reticulum and the Plasma Membrane

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. Cheng-Han Lee,
  2. Damon Poburko,
  3. Kuo-Hsing Kuo,
  4. Chun Seow and
  5. Cornelis van Breemen

Published Online: 7 OCT 2008

DOI: 10.1002/0470853050.ch3

Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246

Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246

How to Cite

Lee, C.-H., Poburko, D., Kuo, K.-H., Seow, C. and van Breemen, C. (2002) Relationship Between the Sarcoplasmic Reticulum and the Plasma Membrane, in Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470853050.ch3

Author Information

  1. The iCAPTUR4E Center, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 and Cardiovascular Sciences, Children's and Women's Health Centre of British Columbia, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1

  1. This chapter was presented at the symposium by Dr van Breemen, to whom correspondence should be addressed

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 15 JUN 2002

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844793

Online ISBN: 9780470853054

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Summary

Ionic interactions between the plasma membrane (PM) and the sarcoplasmic reticulum (SR) play a crucial role in smooth muscle activation and homeostasis. The most common form of Ca2+ signalling seen in vascular smooth muscle of conduit arteries and capacitance veins consists of repetitive asynchronous Ca2+ waves. In the inferior vena cava of the rabbit these waves are initiated by Ca2+ release via InsP3 receptors (InsP3R) and propagated by regenerative Ca2+ release. Maintenance of the [Ca2+]i oscillations is dependent on Ca2+ entry through the Na+/Ca2+-exchanger (NCX) which is driver in the reverse mode by Na+ entry through non-specific cation channels. The latter are also responsible for depolarization and activation of voltage-gated Ca2+ channels. The sarcoplasmic-endoplasmic reticulum Ca2+-ATPase (SERCA) in the sheet-like junctional SR is responsible for refilling and completing the cycle. Under resting conditions the interaction between the superficial SR and the NCX is reversed with Ca2+ release channels supplying Ca2+ to the NCX in the PM to be extruded in exchange of extracellular Na+. It is proposed that the above Ca2+ transport between the SR lumen and the extracellular space takes place at PM–SR junctions across a narrow junctional space.