Calcium Release by Ryanodine Receptors in Smooth Muscle

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. M. I. Kotlikoff,
  2. Yong-Xiao Wang,
  3. Hong-Bo Xin and
  4. Guanju Ji

Published Online: 7 OCT 2008

DOI: 10.1002/0470853050.ch9

Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246

Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246

How to Cite

Kotlikoff, M. I., Wang, Y.-X., Xin, H.-B. and Ji, G. (2002) Calcium Release by Ryanodine Receptors in Smooth Muscle, in Role Of The Sarcoplasmic Reticulum In Smooth Muscle: Novartis Foundation Symposium 246 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470853050.ch9

Author Information

  1. Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 15 JUN 2002

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844793

Online ISBN: 9780470853054

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Summary

Recent experiments have revealed an unanticipated complexity in Ca2+ release processes in smooth muscle. While Ca2+ release via stimulation of phospholipase C activity and the gating of inositol-1,4,5-trisphosphate (InsP3) receptor Ca2+ channels has been well characterized, the role of the homologous family of sarcoplasmic reticulum (SR) Ca2+ channels, ryanodine receptors (RyRs), in excitation-contraction coupling in smooth muscle is less clear. These Ca2+-gated SR Ca2+ channels produce unitary Ca2+ sparks, which in turn open Ca2+-activated membrane ion channels such as Ca2+- activated Cl channels (ClCa) and Ca2+-activated K+ channels. In this manner local Ca2+ sparks trigger spontaneous transient inward and outward currents, thereby driving physiological electrical activity in smooth muscle. Here we summarize some of our recent findings on Ca2+ -induced Ca2+ release (CICR) and stretch-induced Ca2+ release (SICR) in smooth muscle.