Infiltration of Tumours by Macrophages and Dendritic Cells: Tumour-Associated Macrophages as a Paradigm for Polarized M2 Mononuclear Phagocytes
- Derek J. Chadwick Organizer,
- Jamie A. Goode
Published Online: 7 OCT 2008
DOI: 10.1002/0470856734.ch10
Copyright © Novartis Foundation 2004
Book Title
Cancer and Inflammation: Novartis Foundation Symposium 256
Additional Information
How to Cite
Mantovani, A., Sozzani, S., Locati, M., Schioppa, T., Saccani, A., Allavena, P. and Sica, A. (2008) Infiltration of Tumours by Macrophages and Dendritic Cells: Tumour-Associated Macrophages as a Paradigm for Polarized M2 Mononuclear Phagocytes, in Cancer and Inflammation: Novartis Foundation Symposium 256 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470856734.ch10
Publication History
- Published Online: 7 OCT 2008
- Published Print: 23 JAN 2004
ISBN Information
Print ISBN: 9780470855102
Online ISBN: 9780470856734
- Summary
- Chapter
Summary
Macrophages and dendritic cells infiltrate tumours. In the tumour microenvironment, mononuclear phagocytes acquire properties of polarized M2 (or alternatively activated) macrophages. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression.