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Calcium-Binding Proteins

  1. Jenny J. Yang,
  2. Wei Yang

Published Online: 15 MAR 2006

DOI: 10.1002/0470862106.ia032

Encyclopedia of Inorganic Chemistry

Encyclopedia of Inorganic Chemistry

How to Cite

Yang, J. J. and Yang, W. 2006. Calcium-Binding Proteins . Encyclopedia of Inorganic Chemistry. .

Author Information

  1. Georgia State University, Atlanta, GA, USA

Publication History

  1. Published Online: 15 MAR 2006


Ca2+ is an important second messenger in the regulation of cell life cycle in addition to being an essential component in biomineralization. Ca2+ mediates its action in regulation by binding to Ca2+ receptors/proteins that in turn regulate signal transduction, enzymatic activity, and protein stability. During the past few years, owing to the fast progress in genomic information and structural biological studies, our understanding of calcium-binding proteins has been greatly expanded. Since 1991, the structures of calcium-binding proteins have been extended to more than 1000 today and calcium-binding proteins are found in every cellular compartment. In this article, we will first summarize the current knowledge about the common properties of calcium-binding proteins. We then will highlight recent developments in structural biology and biological functions of calcium-binding proteins.


  • calcium-binding proteins;
  • metalloproteins;
  • EF-hand;
  • calmodulin;
  • conformational change;
  • protein–protein interaction;
  • extracellular calcium-binding proteins;
  • calcium signaling, calcium homeostasis;
  • trigger proteins;
  • biometals;
  • signal transduction