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Iron: Heme Proteins, Peroxidases, Catalases & Catalase-Peroxidases

  1. B. Bhaskar,
  2. Latesh Lad,
  3. Thomas L. Poulos

Published Online: 15 MAR 2006

DOI: 10.1002/0470862106.ia106

Encyclopedia of Inorganic Chemistry

Encyclopedia of Inorganic Chemistry

How to Cite

Bhaskar, B., Lad, L. and Poulos, T. L. 2006. Iron: Heme Proteins, Peroxidases, Catalases & Catalase-Peroxidases . Encyclopedia of Inorganic Chemistry. .

Author Information

  1. University of California-Irvine, Irvine, CA, USA

Publication History

  1. Published Online: 15 MAR 2006

Abstract

This article describes recent advances made in understanding structure–function relationships in representative peroxidases, catalases, and catalase-peroxidases. Emphasis will be placed on those enzymes for which crystal structures are available. Of particular interest are recent advances in elucidating the structure of peroxidase compounds I and II, important intermediates that are formed from the reaction of the enzyme with peroxides. The repertoire of known structures in the catalase/peroxidase superfamily now include KatG catalases-peroxidases and di-heme peroxidases. These new structures coupled with a wealth of biochemical and biophysical data have provided important new insights into structure and function.

Keywords:

  • peroxidases;
  • catalases;
  • catalase-peroxidases;
  • Trp π-cation radical;
  • porphyrin π-cation radical;
  • high-resolution structures