Iron Proteins with Mononuclear Active Sites
Published Online: 15 MAR 2006
Copyright © 2006 John Wiley & Sons, Ltd
Encyclopedia of Inorganic Chemistry
How to Cite
Emerson, J. P., Mehn, M. P. and Que, L. 2006. Iron Proteins with Mononuclear Active Sites. Encyclopedia of Inorganic Chemistry. .
- Published Online: 15 MAR 2006
Metalloenzymes containing a mononuclear nonheme iron center are often involved in dioxygen metabolism. We have divided this superfamily of enzymes into seven subcategories: iron superoxide dismutase and superoxide reductase, lipoxygenase, catechol dioxygenases, α-keto acid-dependent enzymes, isopenicillin N synthase, pterin-dependent hydroxylases, and Rieske dioxygenases. The degree of catalytic versatility and coordination flexibility encompassed by these enzymes is unsurpassed by any other known metalloenzyme superfamily. Herein we discuss the present state of knowledge regarding their active site structures and the critical role the metal center plays in their respective catalytic mechanisms.
- model complexes