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Nickel: Models of Protein Active Sites

  1. Wen-Feng Liaw

Published Online: 15 MAR 2006

DOI: 10.1002/0470862106.ia151

Encyclopedia of Inorganic Chemistry

Encyclopedia of Inorganic Chemistry

How to Cite

Liaw, W.-F. 2006. Nickel: Models of Protein Active Sites . Encyclopedia of Inorganic Chemistry. .

Author Information

  1. National Tsing Hua University, Hsinchu, Taiwan

Publication History

  1. Published Online: 15 MAR 2006


During the past decade, structures and functions of the active sites have been established for the nickel-based metalloenzymes present in the hydrogenases, ureases, carbon monoxide dehydrogenases/acetyl coenzyme A synthase, and methyl coenzyme M reductase. Roles of nickel in these Ni-containing enzymes serve as catalytic or redox centers. Model compounds and various biophysical techniques have been lent to elucidate aspects of the structure and function (catalytic mechanism) of the Ni sites in these enzymes. Structures/functions of these Ni-containing enzymes, biomimetic model compound studies, and the proposed catalytic mechanisms are presented.


  • hydrogenase;
  • urease;
  • carbon monoxide dehydrogenase;
  • acetyl coenzyme A synthase;
  • methyl coenzyme M reductase;
  • nickel-containing metalloenzymes;
  • model compounds