Platinum-Based Anticancer Drugs
Published Online: 15 MAR 2006
Copyright © 2006 John Wiley & Sons, Ltd
Encyclopedia of Inorganic Chemistry
How to Cite
Robillard, M. S. and Reedijk, J. 2006. Platinum-Based Anticancer Drugs . Encyclopedia of Inorganic Chemistry.
- Published Online: 15 MAR 2006
The chemotherapeutic agent cisplatin enjoys the status of one of the world's best-selling anticancer drugs. As is the case with other chemotherapeutic drugs, however, cisplatin has its drawbacks, including intrinsic or acquired resistance and toxicity. Efforts to mitigate cisplatin's drawbacks have inspired the synthesis of myriad analogs, but with only a handful that have been shown to be acceptable for clinical application. Increased understanding of the mechanism of the action of cisplatin, as a result of decades of research, is leading to a more rational design of new platinum drugs. However, the incomplete puzzle of cisplatin's ways and the lack of a single decisive biological target for anticancer treatment still complicate the search for improved platinum drugs. This article gives a brief introduction to cisplatin, and subsequently summarizes and evaluates the development of cisplatin derivatives and possible new approaches.