Selenium Proteins Containing Selenocysteine
Published Online: 15 MAR 2006
Copyright © 2006 John Wiley & Sons, Ltd
Encyclopedia of Inorganic Chemistry
How to Cite
Böck, A. 2006. Selenium Proteins Containing Selenocysteine. Encyclopedia of Inorganic Chemistry. .
- Published Online: 15 MAR 2006
Selenium is incorporated in the form of the nonstandard amino acid selenocysteine into selected proteins of organisms belonging to all three lines of descent. The majority of these proteins, which contain selenocysteine in the active site, catalyze oxidation–reduction reactions and are involved in numerous biochemical and regulatory processes, which are indispensable for the organism. Because of the higher chemical reactivity of selenocysteine in comparison to cysteine, selenoenzymes display a greatly increased rate of catalysis. Apart from its biochemical function, selenocysteine is also unique since its incorporation is DNA-encoded and its cotranslational insertion follows a route independent in many features from the path of insertion of the 20 classical amino acids. Selenocysteine, therefore, can be considered the 21st amino acid.
- nonstandard amino acid;
- translation factor SelB;
- selenocysteine synthesis;