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Alkane Carbon–Hydrogen Bond Activation

  1. Robert H. Crabtree

Published Online: 15 MAR 2006

DOI: 10.1002/0470862106.ia298

Encyclopedia of Inorganic Chemistry

Encyclopedia of Inorganic Chemistry

How to Cite

Crabtree, R. H. 2006. Alkane Carbon–Hydrogen Bond Activation. Encyclopedia of Inorganic Chemistry. .

Author Information

  1. Yale University, New Haven, CT, USA

Publication History

  1. Published Online: 15 MAR 2006


The title topic is reviewed with attention to alkane complexes, Shilov chemistry, alkane functionalization, Fenton reagents, oxidative addition pathways, sigma bond metathesis pathways, and surface-bound reagents. Methane to methanol chemistry is discussed and attempts to commercialize the reaction are described in connection with Periana systems. Some organic synthetic applications are also covered. Future challenges are posed.


  • alkane functionalization;
  • alkane complexes;
  • oxidative addition;
  • sigma bond metathesis;
  • Fenton chemistry;
  • Shilov chemistry