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Medicinal Inorganic Chemistry: An Introduction

  1. Katherine H. Thompson

Published Online: 15 DEC 2010

DOI: 10.1002/0470862106.ia470

Encyclopedia of Inorganic Chemistry

Encyclopedia of Inorganic Chemistry

How to Cite

Thompson, K. H. 2010. Medicinal Inorganic Chemistry: An Introduction. Encyclopedia of Inorganic Chemistry. .

Author Information

  1. University of British Columbia, Vancouver, BC, Canada

Publication History

  1. Published Online: 15 DEC 2010

Abstract

Metal ions in clinical use today include bismuth compounds, which have been in use for over a hundred years, lithium carbonate, which has been in use for over 50 years, and cisplatin, which was introduced almost 40 years ago. “Metals in medicine” also covers a wealth of newer diagnostic and therapeutic compounds, such as gadolinium-based contrast agents for magnetic resonance imaging (MRI), samarium-based compounds for relief of bone pain in intractable cancer, and lanthanum carbonate for the treatment of hyperphosphatemia. In the process, mystical/magical use of metals in medicine has given way to rational design and testing of new metallopharmaceutical compounds. Advances in our understanding of bioinorganic chemistry and increasingly sensitive analytical instrumentation enable an accelerated pace of development in medicinal inorganic chemistry.

Keywords:

  • therapeutic;
  • diagnostic;
  • arsphenamine;
  • auranofin;
  • metals in medicine;
  • lithium carbonate;
  • bismuth subsalicylate;
  • barium sulfate;
  • cisplatin;
  • technetium;
  • samarium