Chapter 13. Functional In Silico Analysis of Non-Coding SNPs
- Michael R. Barnes2,
- Ian C. Gray3
Published Online: 22 MAY 2003
DOI: 10.1002/0470867302.ch13
Copyright © 2003 John Wiley & Sons, Ltd
Book Title
Bioinformatics for Geneticists
Additional Information
How to Cite
Werner, T. (2003) Functional In Silico Analysis of Non-Coding SNPs, in Bioinformatics for Geneticists (eds M. R. Barnes and I. C. Gray), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867302.ch13
Editor Information
- 2
Genetic Bioinformatics, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex CM19 5AW, UK
- 3
Discovery Genetics, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park (North), Third Avenue, Harlow, Essex CM19 5AW, UK
Publication History
- Published Online: 22 MAY 2003
- Published Print: 21 FEB 2003
ISBN Information
Print ISBN: 9780470843932
Online ISBN: 9780470867303
- Summary
- Chapter
Summary
This chapter contains sections titled:
Introduction
General Structure of Chromatin-associated DNA
General Functions of Regulatory Regions
Transcription Factor Binding Sites (TF-sites)
Structural Elements
Organizational Principles of Regulatory Regions
RNA Processing
SNPs in Regulatory Regions
Evaluation of Non-coding SNPs
SNPs and Regulatory Networks
SNPs May Affect the Expression of a Gene Only in Specific Tissues
In Silico Detection and Evaluation of Regulatory SNPs
Getting Promoter Sequences
Identification of Relevant Regulatory Elements
Estimation of Functional Consequences of Regulatory SNPs
Conclusion
References