Hyaluronan-Based Scaffolds (Hyalograft® C) in the Treatment of Knee Cartilage Defects: Preliminary Clinical Findings

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Alessandra Pavesio1,
  2. Giovanni Abatangelo2,
  3. Anna Borrione1,
  4. Domenico Brocchetta3,
  5. Anthony P. Hollander6,
  6. Elizaveta Kon4,
  7. Francesca Torasso1,
  8. Stefano Zanasi5 and
  9. Maurilio Marcacci4

Published Online: 7 OCT 2008

DOI: 10.1002/0470867973.ch15

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

How to Cite

Pavesio, A., Abatangelo, G., Borrione, A., Brocchetta, D., Hollander, A. P., Kon, E., Torasso, F., Zanasi, S. and Marcacci, M. (2003) Hyaluronan-Based Scaffolds (Hyalograft® C) in the Treatment of Knee Cartilage Defects: Preliminary Clinical Findings, in Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867973.ch15

Author Information

  1. 1

    Fidia Advanced Biopolymers srl, Via Ponte della Fabbrica 3/B, 35031 Abano Terme (PD), Italy

  2. 2

    Institute of Histology and Embriology, Faculty of Medicine, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy

  3. 3

    Istituto Clinico S. Ambrogio, Reparto di Ortopedia, Via Faravelli 16, 20149 Milano, Italy

  4. 4

    Istituti Ortopedici Rizzoli, Laboratorio di Biomeccanica, Via Di Barbiano 1/10, 40136 Bologna, Italy

  5. 5

    Policlinico di Monza, Reparto di Ortopedia, Via Amati 111, 20052 Monza, Italy

  6. 6

    University of Bristol Academic Rheumatology, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 11 MAR 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844816

Online ISBN: 9780470867976

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Summary

Hyalograft® C is an innovative tissue-engineering approach for the treatment of knee cartilage defects involving the implantation of laboratory expanded autologous chondrocytes grown on a three-dimensional hyaluronan-based scaffold. This technique has recently been introduced into clinical practice, with more than 600 patients treated so far. Because no periosteal coverage is required to keep the graft in place, surgical time and morbidity are reduced, and handling of the graft is much simpler than currently available autologous chondrocyte implantation techniques. The safety profile of the treatment appears positive, with a limited number of adverse events reported. Here we discuss the clinical, arthroscopic and histological results from a cohort of 67 patients treated with Hyalograft® C (mean follow-up time from implantation of 17.5 months). Results are reported based on four endpoints: patients' subjective evaluation of knee conditions (97% of patients improved) and quality of life (94% improved), surgeons' knee functional test (87% of patients with the best scores), arthroscopic evaluation of cartilage repair (96.7% biologically acceptable) and histological assessment of the grafted site (majority of specimens hyaline-like). The positive clinical results obtained indicate that Hyalograft® C may be a viable therapeutic option for the treatment of acute cartilage lesions.