Tissue Engineering of Cartilage: Do We Need It, Can We Do It, Is It Good and Can We Prove It?

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. L. Stefan Lohmander

Published Online: 7 OCT 2008

DOI: 10.1002/0470867973.ch2

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

How to Cite

Lohmander, L. S. (2008) Tissue Engineering of Cartilage: Do We Need It, Can We Do It, Is It Good and Can We Prove It?, in Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867973.ch2

Author Information

  1. Department of Orthopedics, University Hospital Lund, SE-22185 Lund, Sweden

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 11 MAR 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844816

Online ISBN: 9780470867976

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Summary

Current treatments of osteoarthritis (OA) focus on pain and loss of joint function. When these interventions fail, the destroyed joint is replaced by implants of metal, plastic and ceramics. In the future, we need to detect cartilage loss before it is too severe, prevent further loss and stimulate regrowth of lost cartilage. Research in tissue engineering can help us understand the complex requirements for regeneration of joint cartilage. Results from animal experiments and small, uncontrolled, open series of human cartilage repair suggest that functional repair can be accomplished in some joints in some patients. However, outcome is inconsistent. Do we need to recreate the original hyaline joint cartilage or will something else work as well? It is far from clear what factors determine a successful repair or what method is best. The durability of repair tissue is uncertain. The cost–benefit equation is unresolved, and current surgical interventions are associated with significant cost and morbidity. What is the ‘number-needed-to-treat’ to prevent one knee/patient lost to early retirement or future OA? The outcome measures used to determine success or failure of the repair deal with cartilage, joint and patient. The relationship between these outcome dimensions is unclear. However, the outcome as judged by the patient using standardized measures is the gold standard.