The Fundamentals of Tissue Engineering: Scaffolds and Bioreactors

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Gordana Vunjak-Novakovic

Published Online: 7 OCT 2008

DOI: 10.1002/0470867973.ch4

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

How to Cite

Vunjak-Novakovic, G. (2003) The Fundamentals of Tissue Engineering: Scaffolds and Bioreactors, in Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867973.ch4

Author Information

  1. Massachusetts Institute of Technology, Harvard-MIT Division of Health Sciences and Technology, Cambridge MA 02139, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 11 MAR 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844816

Online ISBN: 9780470867976

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Summary

Tissue engineering has the potential to provide cartilaginous constructs capable of restoring the normal function of native articular cartilage following joint injury or degradation. One approach to functional tissue engineering of cartilage involves the in vitro cultivation of tissue constructs by using: (i) chondrogenic cells that can be selected, expanded, and transfected to overexpress the genes of interest, (ii) scaffolds that provide a defined three-dimensional structure for tissue development and biodegrade at a controlled rate, and (iii) bioreactors that provide the conditions necessary for the cells to regenerate functional cartilaginous tissues. Here we explore the paradigm of tissue-engineered cartilage repair that is based on the generation of immature but functional constructs in vitro, and the remodelling and maturation of these constructs in vivo.