Tissue-Engineered Versus Native Cartilage: Linkage between Cellular Mechano-Transduction and Biomechanical Properties

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Jennifer H. Lee1,
  2. John Kisiday1 and
  3. Alan J. Grodzinsky1,2,3,†

Published Online: 7 OCT 2008

DOI: 10.1002/0470867973.ch5

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

How to Cite

Lee, J. H., Kisiday, J. and Grodzinsky, A. J. (2003) Tissue-Engineered Versus Native Cartilage: Linkage between Cellular Mechano-Transduction and Biomechanical Properties, in Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867973.ch5

Author Information

  1. 1

    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge MA 02139-4307, USA

  2. 2

    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge MA 02139-4307, USA

  3. 3

    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge MA 02139-4307, USA

  1. This paper was presented at the symposium by Alan J. Grodzinsky to whom correspondence should be addressed.

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 11 MAR 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844816

Online ISBN: 9780470867976

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Summary

Recent studies demonstrate that chondrocytes in native articular cartilage and in tissue-engineered constructs respond to mechanical stimuli through multiple regulatory pathways. Responses of the cells are manifested by intra- and intercellular signalling, alterations in transcription level, protein translation, post-translational modifications, and synthesis of intracellular and extracellular macromolecules. In addition, mechanical stimuli can alter the balance between anabolic and catabolic processes that are critically important to cell-mediated extracellular assembly and degradation of the tissue matrix and, therefore, to the survival of tissue engineered constructs. Chondrocyte mechanotransduction is therefore a critically important link to the biomechanical properties of native cartilage and to developing constructs. Since implanted cartilage repair tissue will be subjected to mechanical loads throughout its lifetime, it is essential that the resident cells respond appropriately to the range of static and dynamic compressive and shear deformations in vivo in a manner that enables adaptive remodelling and minimizes catabolic degradation. The in vivo environment should thereby signal tissue-specific maturation and integration processes in order to achieve the most appropriate tissue morphology and biomechanical function.