Differentiated Chondrocytes for Cartilage Tissue Engineering

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. J. Huckle1,
  2. G. Dootson1,
  3. N. Medcalf1,
  4. S. McTaggart1,
  5. E. Wright1,
  6. A. Carter1,
  7. R. Schreiber2,
  8. B. Kirby2,
  9. N. Dunkelman2,
  10. S. Stevenson2,
  11. S. Riley2,
  12. T. Davisson2 and
  13. A. Ratcliffe2

Published Online: 7 OCT 2008

DOI: 10.1002/0470867973.ch8

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249

How to Cite

Huckle, J., Dootson, G., Medcalf, N., McTaggart, S., Wright, E., Carter, A., Schreiber, R., Kirby, B., Dunkelman, N., Stevenson, S., Riley, S., Davisson, T. and Ratcliffe, A. (2003) Differentiated Chondrocytes for Cartilage Tissue Engineering, in Tissue Engineering of Cartilage and Bone: Novartis Foundation Symposium 249 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470867973.ch8

Author Information

  1. 1

    Smith & Nephew Group Research Centre, York Science Park, Heslington, York YO10 5DF, UK

  2. 2

    Advanced Tissue Sciences, Inc, 10933 North Torrey Pines Road, La Jolla, CA 92037-1005, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 11 MAR 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470844816

Online ISBN: 9780470867976

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Summary

Trauma to the articular cartilage surface of the joint represents a challenging clinical problem due to the very limited ability of this tissue to self-repair. Moreover, repair techniques such as microfracture, which introduce cells into the joint, have unpredictable clinical outcomes as they produce a fibrocartilage tissue that degenerates with time. Alternative treatments include tissue reconstruction with autograft and allograft tissue. However, these procedures are restricted by the availability of suitable donor tissue. These limitations have been the driving force behind the emerging field of articular cartilage tissue engineering. This paper will highlight and contrast the key challenges associated with the tissue engineering of this neo-tissue using differentiated adult cells. The various components of the tissue engineering process will be described including the choice of donor cell/tissue type and the selection of scaffolds that guide the formation of tissue. The ability of the tissue engineered implants to stimulate the repair of defects in vivo will also be discussed. Tissue engineering approaches may, in the future, provide an ideal alternative to the current surgical treatments for cartilage repair.