Patterning of the Mouse Conduction System

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Stacey Rentschler1,
  2. Gregory E. Morley2 and
  3. Glenn I. Fishman2,*

Published Online: 7 OCT 2008

DOI: 10.1002/0470868066.ch12

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

How to Cite

Rentschler, S., Morley, G. E. and Fishman, G. I. (2003) Patterning of the Mouse Conduction System, in Development of the Cardiac Conduction System: Novartis Foundation Symposium 250 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470868066.ch12

Author Information

  1. 1

    Mount Sinai School of Medicine, Box 1102, One Gustave L. Levy Place, New York, NY 10029-6754, USA

  2. 2

    New York University School of Medicine, Division of Cardiology, 550 First Avenue, OBV-A615, New York, NY 10016-9196, USA

*New York University School of Medicine, Division of Cardiology, 550 First Avenue, OBV-A615, New York, NY 10016-9196, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 20 JUN 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470850350

Online ISBN: 9780470868065

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Summary

The cardiac conduction system (CCS) is a network of cells responsible for the rhythmic and coordinated excitation of the heart. Components of the murine conduction system, including the peripheral Purkinje fibres, are morphologically indistinguishable from surrounding cardiomyocytes and there exists a paucity of molecular markers to specifically identify these cells. Recently, we identified a line of transgenic mice in which the lacZ reporter gene is expressed within the embryonic CCS beginning at 8.25 days post-conception (dpc); its expression appears to delineate the full extent of the CCS, including the distal Purkinje fibre network, throughout all subsequent stages of development. Moreover, using the highly sensitive technique of optical mapping of electrical activity in embryonic murine hearts, we provided evidence for functional specialization of components of the CCS as early as 10.5 dpc. Here, we summarize these findings and describe our initial efforts utilizing the CCS-lacZ mice to identify novel factors that promote CCS specialization.