Clinical Pathology of the Cardiac Conduction System

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Siew Yen Ho

Published Online: 7 OCT 2008

DOI: 10.1002/0470868066.ch13

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

How to Cite

Ho, S. Y. (2003) Clinical Pathology of the Cardiac Conduction System, in Development of the Cardiac Conduction System: Novartis Foundation Symposium 250 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470868066.ch13

Author Information

  1. Faculty of Medicine, Paediatrics, National Heart & Lung Institute, Royal Brompton Campus, Imperial College, Dovehouse Street, London SW3 6LY, UK

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 20 JUN 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470850350

Online ISBN: 9780470868065

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Summary

Abnormal architecture of the conduction system affects both the normally structured and the congenitally malformed heart. While the majority of malformed hearts have more-or-less normal arrangements of the conduction system, there are others with significant deviations. In particular, the derangements are related to malalignment of the ventricular septum in the case of the atrioventricular conduction tissues, and to atrial arrangement with regard to the sinus node. Congenital heart block can occur in isolation or in association with congenital heart defects. The anatomical substrate in heart block is an interruption of the atrioventricular conduction system. Lesions of the conduction system are also found in cases of sudden cardiac death in adults. Whether such lesions are congenital or ‘acquired’ as part of the ageing process remains to be clarified.