Mouse Models for Cardiac Conduction System Development

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Andy Wessels1,
  2. Aimee Phelps1,
  3. Thomas C. Trusk1,
  4. Dorene L. Davis2,
  5. Angela V. Edwards2,
  6. John B. E. Burch2 and
  7. Amy L. Juraszek1,3

Published Online: 7 OCT 2008

DOI: 10.1002/0470868066.ch4

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

How to Cite

Wessels, A., Phelps, A., Trusk, T. C., Davis, D. L., Edwards, A. V., Burch, J. B. E. and Juraszek, A. L. (2008) Mouse Models for Cardiac Conduction System Development, in Development of the Cardiac Conduction System: Novartis Foundation Symposium 250 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470868066.ch4

Author Information

  1. 1

    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 172 Ashley Avenue, Charleston SC29425, USA

  2. 2

    Department of Cell and Developmental Biology, Fox Chase Cancer Center, 7701 Burbolme Avenue, Philadelphia, PA 19111, USA

  3. 3

    Division of Pediatric Cardiology, Medical University of South Carolina, 172 Ashley Avenue, Charleston SC 29425, USA

  1. This paper is dedicated to the memory of Szabolcs Viragh (1930–2001), cardiovascular embryologist, mentor, and friend who during his scientific career educated many of us on the morphological aspects of the development of the heart conduction system in the mouse (Viragh & Porte 1973a, 1973b, Viragh & Challice 1977a, 1977b, 1978, 1980, 1982, 1983, Viragh et al 1987, 1988).

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 20 JUN 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470850350

Online ISBN: 9780470868065

SEARCH

Summary

The mouse is the animal of choice for the study of molecular mechanisms involved in the regulation of cardiovascular morphogenesis and function. Recently, a series of genetically engineered mouse models have been reported (e.g. cGATA6/lacZ, MinK/lacZ knock-in/knock-out, engrailed2/lacZ, Cardiac troponin I/lacZ) that provide new and exciting information on the development of the atrioventricular conduction system (AVCS). On the basis of these and ongoing studies, concepts for the formation of the AVCS are continuously being adjusted. A proper understanding of the normal developmental mechanisms underlying the cardiac remodelling leading to the formation of the AVCS is imperative for the interpretation of cardiac abnormalities, including conduction disturbances, as observed in some genetically perturbed (knockout) mice. In this paper information on murine AVCS development will be integrated with published and unpublished results from studies in other vertebrates, including human and rabbit. We will illustrate that although many pieces of the puzzle still remain to be gathered, the outline of a very complex and critical event in cardiac morphogenesis is slowly emerging. Specifically, we will re-evaluate the concept of the ‘primary ring’ in the context of the new insights in the development of the AV junction as provided by the respective mouse models described above.