The Role of Neural Crest and Epicardium-Derived Cells in Conduction System Formation

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Adriana C. Gittenberger-de Groot,
  2. Nico M. Blom,
  3. Naoyoshi Aoyama,
  4. Henri Sucov,
  5. Arnold C. G. Wenink and
  6. Robert E. Poelmann

Published Online: 7 OCT 2008

DOI: 10.1002/0470868066.ch8

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

Development of the Cardiac Conduction System: Novartis Foundation Symposium 250

How to Cite

Gittenberger-de Groot, A. C., Blom, N. M., Aoyama, N., Sucov, H., Wenink, A. C. G. and Poelmann, R. E. (2008) The Role of Neural Crest and Epicardium-Derived Cells in Conduction System Formation, in Development of the Cardiac Conduction System: Novartis Foundation Symposium 250 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470868066.ch8

Author Information

  1. Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9602, Leiden, 2300 RC, The Netherlands

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 20 JUN 2003

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470850350

Online ISBN: 9780470868065

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Summary

During cardiac development the heart tube loops and is septated into a four-chambered structure. The initial peristaltic contraction of the primitive myocardium is replaced by a system of working myocardium and a myocardial-derived central and peripheral conduction system. The genes guiding this differentiation process are still under investigation and it has yet to be decided whether we are dealing with a recruitment or a specification model. We have shown that the complicated looping process of the heart tube brings together the essential parts of the sinoatrial and primary ring myocardium, that are the embryonic precursors of the definitive conduction system. From our studies it is evident that during development there are sinoatrial tracts that run between the sinoatrial and the atrioventricular node as well as tracts surrounding the pulmonary veins and the coronary sinus. Furthermore, we show that both in the chicken and mouse embryo neural crest cells reach the confinement of the central conduction system through the inflow and outflow tract. For the Purkinje system there is a close approximation with the epicardium-derived cells. We postulate that both extracardiac-derived cell types have an influence on the differentiation of the definitive conduction system.