Chapter 9. Spectroscopy: 1H Metabolite Concentrations

  1. Paul Tofts
  1. Paul S. Tofts2 and
  2. Adam D. Waldman1,‡

Published Online: 8 JUL 2004

DOI: 10.1002/0470869526.ch9

Quantitative MRI of the Brain: Measuring Changes Caused by Disease

Quantitative MRI of the Brain: Measuring Changes Caused by Disease

How to Cite

Tofts, P. S. and Waldman, A. D. (2003) Spectroscopy: 1H Metabolite Concentrations, in Quantitative MRI of the Brain: Measuring Changes Caused by Disease (ed P. Tofts), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470869526.ch9

Editor Information

  1. NMR Research Unit, Department of Neuroinflammation and Medical Physics, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK

Author Information

  1. 1

    Dementia Research Group, Institute of Neurology, London, WC1N 3BG, UK and Department of Imaging, Charing Cross and Hammersmith Hospitals, London, UK

  2. 2

    NMR Research Unit, Department of Neuroinflammation and Medical Physics, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK

  1. Adam Waldman contributed Sections 9.3 and 9.6 (including the table and figures).

  1. Reviewed by Roland Kreis, ‘Privatdozent’, Department of Clinical Research, MR Unit, University Berne, MR Centre 1. CH-3010 Berne, Switzerland and Else Danielsen, Department of Radiology, Rigshospitalet, Copenhagen, Denmark.

Publication History

  1. Published Online: 8 JUL 2004
  2. Published Print: 15 AUG 2003

ISBN Information

Print ISBN: 9780470847213

Online ISBN: 9780470869529

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Summary

This chapter contains sections titled:

  • Introduction

  • Physical Principles of Quantitative Spectroscopy

  • Biological Significance of Metabolite Peaks

  • Quantification of the Metabolite Concentrations – Practical Issues

  • Unwanted Factors Which Can Alter the Measured Value of Metabolite Concentration

  • Clinical Applications of MRS in Neurological Disease

  • Future Methodological Improvements and Clinical Applications

  • References