Neural Stem Cells Are Uniquely Suited for Cell Replacement and Gene Therapy in the CNS

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. Vaclav Ourednik1,
  2. Jitka Ourednik1,
  3. Kook I. Park1,2,
  4. Y. D. Teng1,
  5. Karen A. Aboody1,
  6. Kurtis I. Auguste1,
  7. Rosanne M. Taylor3,
  8. Barbara A. Tate1 and
  9. Evan Y. Snyder1,*

Published Online: 7 OCT 2008

DOI: 10.1002/0470870834.ch15

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

How to Cite

Ourednik, V., Ourednik, J., Park, K. I., Teng, Y. D., Aboody, K. A., Auguste, K. I., Taylor, R. M., Tate, B. A. and Snyder, E. Y. (2000) Neural Stem Cells Are Uniquely Suited for Cell Replacement and Gene Therapy in the CNS, in Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470870834.ch15

Author Information

  1. 1

    Departments of Neurology (Division of Neuroscience), Pediatrics (Division of Newborn Medicine), & Neurosurgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

  2. 2

    Department of Pediatrics, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, Korea

  3. 3

    University of Sydney, Department of Animal Science, Sydney, Australia

*Departments of Neurology (Division of Neuroscience), Pediatrics (Division of Newborn Medicine), & Neurosurgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 23 OCT 2000

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471492467

Online ISBN: 9780470870839

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Summary

In recent years, it has become evident that the developing and even the adult mammalian CNS contain a population of undifferentiated, multipotent cell precursors, neural stem cells, the plastic properties of which might be of advantage for the design of more effective therapies for many neurological diseases. This article reviews the recent progress in establishing rodent and human clonal neural stem cell lines, their biological properties, and how these cells can be utilized to correct a variety of defects, with prospects for the near future to harness their behaviour for neural stem cell-based treatment of diseases in humans.