Repair of Corticospinal Axons by Transplantation of Olfactory Ensheathing Cells

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. Geoff Raisman

Published Online: 7 OCT 2008

DOI: 10.1002/0470870834.ch6

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

How to Cite

Raisman, G. (2000) Repair of Corticospinal Axons by Transplantation of Olfactory Ensheathing Cells, in Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470870834.ch6

Author Information

  1. Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW 71 AA, UK

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 23 OCT 2000

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471492467

Online ISBN: 9780470870839

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Summary

This paper examines the possibility of repairing cut central connections by transplantation of glial cells which modify the glial pathways and take advantage of the inherent growth capacity in adult neurons. We found that transplants of cultured olfactory ensheathing cells into lesions of the adult rat corticospinal tract induced long growth of cut axons across the lesion. Acquisition of a directed forepaw reaching function was restored on the operated side.