Transplantation of Human Fetal Striatal Tissue in Huntington's Disease: Rationale for Clinical Studies

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. Thomas B. Freeman1,
  2. Robert A. Hauser2,
  3. Alison E. Willing3,
  4. Tanja Zigova4,
  5. Paul R. Sanberg1 and
  6. Samuel Saporta5

Published Online: 7 OCT 2008

DOI: 10.1002/0470870834.ch8

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231

How to Cite

Freeman, T. B., Hauser, R. A., Willing, A. E., Zigova, T., Sanberg, P. R. and Saporta, S. (2000) Transplantation of Human Fetal Striatal Tissue in Huntington's Disease: Rationale for Clinical Studies, in Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231 (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470870834.ch8

Author Information

  1. 1

    Department of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA

  2. 2

    Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, Department of Neurology, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA

  3. 3

    Department of Neurosurgery, The Neuroscience Program, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA

  4. 4

    Department of Neurosurgery, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA

  5. 5

    Department of Neurosurgery, The Neuroscience Program, Department of Anatomy, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 23 OCT 2000

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780471492467

Online ISBN: 9780470870839

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Summary

Huntington's disease is a fatal neurological disorder characterized by chorea and deterioration in cognitive and neuropsychiatric function. Primary pathological changes are found in the striatum, where GABAergic neurons undergo degenerative changes. Local interneurons are relatively spared. Here, we describe the rationale for clinical trials of fetal striatal tissue transplantation for the treatment of Huntington's disease. Specifically, the reasons for utilizing tissue derived from the far lateral aspect of the lateral ventricular eminence as a source of striatal tissue will be discussed.