Unit

UNIT 1.3 Transgenic Animals in Toxicology

  1. Warren C. Ladiges,
  2. Carol B. Ware

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0103s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Ladiges, W. C. and Ware, C. B. 2001. Transgenic Animals in Toxicology. Current Protocols in Toxicology. 00:1.3:1.3.1–1.3.26.

Author Information

  1. University of Washington, Seattle, Washington

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999

Abstract

Transgenic animals are a powerful tool in the exploration of the interaction of specific genes with the environment and/or toxins to understand the relation between biochemical and metabolic pathways and toxic effect. This overview discusses DNA construct design, methods for production of transgenic animals, including pronuclear fusion, gene targeting and chimera production, animal husbandry, and colony management.