UNIT 1.3 Transgenic Animals in Toxicology
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Ladiges, W. C. and Ware, C. B. 2001. Transgenic Animals in Toxicology. Current Protocols in Toxicology. 00:1.3:1.3.1–1.3.26.
- Published Online: 1 MAY 2001
- Published Print: MAY 1999
Transgenic animals are a powerful tool in the exploration of the interaction of specific genes with the environment and/or toxins to understand the relation between biochemical and metabolic pathways and toxic effect. This overview discusses DNA construct design, methods for production of transgenic animals, including pronuclear fusion, gene targeting and chimera production, animal husbandry, and colony management.