Unit

UNIT 1.4 DNA Microarrays: An Overview of Technologies and Applications to Toxicology

  1. Helmut Zarbl

Published Online: 1 NOV 2001

DOI: 10.1002/0471140856.tx0104s09

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Zarbl, H. 2001. DNA Microarrays: An Overview of Technologies and Applications to Toxicology. Current Protocols in Toxicology. 9:1.4:1.4.1–1.4.16.

Author Information

  1. N.I.E.H.S./University of Washington Center for Ecogenetics and Environmental Health and Fred Hutchinson Cancer Research Center, Seattle, Washington

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: AUG 2001

Abstract

DNA microarrays or chips can be used to simultaneously monitor the expression levels and/or genotypes of thousands of genes. The application of these techniques heralds a new era in toxicology research, where genotypes and toxicant-induced expression signatures may be used to monitor cellular responses to different doses, to classify toxins on the basis of their mechanisms of action, to monitor exposures, and to predict individual variability in toxicant sensitivity. This unit reviews the current state of microarray technologies and discusses potential applications in toxicology, with emphasis on the strengths and limitations of the technologies.