Unit

UNIT 1.7 Zebrafish: An Animal Model for Toxicological Studies

  1. Chaojie Zhang1,
  2. Catherine Willett1,
  3. Trisha Fremgen2

Published Online: 1 NOV 2003

DOI: 10.1002/0471140856.tx0107s17

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Zhang, C., Willett, C. and Fremgen, T. 2003. Zebrafish: An Animal Model for Toxicological Studies. Current Protocols in Toxicology. 17:1.7:1.7.1–1.7.18.

Author Information

  1. 1

    Phylonix Pharmaceuticals, Cambridge, Massachusetts

  2. 2

    Northeastern University, Boston, Massachusetts

Publication History

  1. Published Online: 1 NOV 2003
  2. Published Print: AUG 2003

Abstract

Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening.

Keywords:

  • zebrafish;
  • animal model;
  • toxicity;
  • developmental toxicity;
  • drug testing