UNIT 1.8 Preclinical Models of Parkinson's Disease
Published Online: 1 FEB 2004
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Bankiewicz, K. S., Sanchez-Pernaute, R., Oiwa, Y., Kohutnicka, M., Cummins, A. and Eberling, J. 2004. Preclinical Models of Parkinson's Disease. Current Protocols in Toxicology. 18:1.8:1.8.1–1.8.31.
- Published Online: 1 FEB 2004
- Published Print: NOV 2003
Parkinson's disease (PD) is a neurodegenerative disorder in which pigmented midbrain neurons progressively die producing a dopamine (DA) deficit in the striatum, which manifests as an akinetic movement disorder. Experimentally induced striatal DA depletion in animals is a valid model of parkinsonism. The capacity of certain substances to damage catecholaminergic neurons has been used extensively to produce DA deficiency in animals. This unit describes methods for inducing parkinsonism in nonhuman primates and rodents using the neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA). Additionally, procedures for evaluating the animals are presented.