UNIT 2.1 Current Concepts in Cell Toxicity

  1. Afshin Samali,
  2. Boris Zhivotovsky,
  3. Sten Orrenius

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0201s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Samali, A., Zhivotovsky, B. and Orrenius, S. 2001. Current Concepts in Cell Toxicity. Current Protocols in Toxicology. 00:2.1:2.1.1–2.1.16.

Author Information

  1. Karolinska Institutet, Stockholm, Sweden

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999


This overview provides a basic definition of cellular death and the mechanisms that are associated with cell death: apoptosis and necrosis. It includes a description of structural changes and macromolecular degradation and the roles of signaling, mitochondria, and genetic changes in the two forms of cell death.