Unit

UNIT 2.13 Mouse Models for Human Hemato-Lymphopoiesis

  1. Patrick Ziegler,
  2. Markus G. Manz

Published Online: 1 FEB 2007

DOI: 10.1002/0471140856.tx0213s31

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Ziegler, P. and Manz, M. G. 2007. Mouse Models for Human Hemato-Lymphopoiesis. Current Protocols in Toxicology. 31:2.13:2.13.1–2.13.10.

Author Information

  1. Institute for Research in Biomedicine, Bellinzona, Switzerland

Publication History

  1. Published Online: 1 FEB 2007
  2. Published Print: FEB 2007

Abstract

By transplanting human hematopoietic stem and progenitor cells in newborn immunodeficient mice, researchers have recently achieved development of a human adaptive immune system, consisting of B cells, T cells, dendritic cells, and some cells of the myeloid lineage, which together form respective structured lymphoid organs as thymus, spleen, and lymph nodes, and produce some functional immune responses. These will provide valuable models to analyze the impact of chemicals, pharmaceuticals, or species-specific infections on human hematolymphoid cells in vivo. This unit describes methods for isolation of the progenitor human cells and their injection into mouse to constitute an adaptive immune system.

Keywords:

  • xenogeneic mouse models;
  • immunology;
  • hemato-lymphopoiesis