UNIT 3.4 Cell Transformation Assays

  1. Max Costa,
  2. Jessica E. Sutherland

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0304s01

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Costa, M. and Sutherland, J. E. 2001. Cell Transformation Assays. Current Protocols in Toxicology. 1:3.4:3.4.1–3.4.9.

Author Information

  1. New York University School of Medicine, New York, New York

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: AUG 1999


Morphological transformation of mammalian cells following exposure to a chemical agent is frequently used as a preliminary screen for the carcinogenic potential of the agent. This unit describes a protocol using Syrian hamster embryo (SHE) cells to assay transformation.