UNIT 3.7 Assays for Detecting Chromosomal Aberrations

  1. Catherine B. Klein,
  2. Limor Broday,
  3. Max Costa

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0307s03

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Klein, C. B., Broday, L. and Costa, M. 2001. Assays for Detecting Chromosomal Aberrations. Current Protocols in Toxicology. 3:3.7:3.7.1–3.7.16.

Author Information

  1. New York University school of Medicine, New York, New York

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: FEB 2000


This unit describes the techniques used to investigate chromosome structure to detect changes induced by toxicant exposure. Protocols are included for detecting microcucleus (MN) formation, changes in banding patterns by Giemsa banding or fluorescence in situ hybridization (FISH) using chromosome-specific probes, and sister chromatid exchange (SCE) in cultures of established cell lines.