UNIT 3.7 Assays for Detecting Chromosomal Aberrations
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Klein, C. B., Broday, L. and Costa, M. 2001. Assays for Detecting Chromosomal Aberrations. Current Protocols in Toxicology. 3:3.7:3.7.1–3.7.16.
- Published Online: 1 MAY 2001
- Published Print: FEB 2000
This unit describes the techniques used to investigate chromosome structure to detect changes induced by toxicant exposure. Protocols are included for detecting microcucleus (MN) formation, changes in banding patterns by Giemsa banding or fluorescence in situ hybridization (FISH) using chromosome-specific probes, and sister chromatid exchange (SCE) in cultures of established cell lines.