Unit

UNIT 4.31 An Overview of Arsenic Metabolism and Toxicity

  1. Zuzana Drobna1,
  2. Miroslav Styblo1,2,
  3. David J. Thomas3

Published Online: 1 NOV 2009

DOI: 10.1002/0471140856.tx0431s42

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Drobna, Z., Styblo, M. and Thomas, D. J. 2009. An Overview of Arsenic Metabolism and Toxicity. Current Protocols in Toxicology. 42:4.31:4.31.1–4.31.6.

Author Information

  1. 1

    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  2. 2

    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  3. 3

    Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina

Publication History

  1. Published Online: 1 NOV 2009
  2. Published Print: NOV 2009

Abstract

It is likely that at least some of the toxic and carcinogenic effects associated with exposure to inorganic arsenic are, in fact, due to actions of its methylated metabolites. Here, we provide an overview of current models for the biological methylation of arsenicals. This information provides a context for understanding the chemical, biochemical, and genetic approaches to elucidation of the formation and function of methylated arsenicals, which are presented in the following units in this chapter. Curr. Protoc. Toxicol. 42:4.31.1-4.31.6. © 2009 by John Wiley & Sons, Inc.

Keywords:

  • inorganic arsenic;
  • methylated arsenic metabolites;
  • As;
  • methyltransferase