Unit

UNIT 5.4 Isolated Perfused Porcine Skin Flap

  1. Ronald E. Baynes

Published Online: 1 AUG 2001

DOI: 10.1002/0471140856.tx0504s08

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Baynes, R. E. 2001. Isolated Perfused Porcine Skin Flap. Current Protocols in Toxicology. 8:5.4:5.4.1–5.4.9.

Author Information

  1. North Carolina State University, Raleigh, North Carolina

Publication History

  1. Published Online: 1 AUG 2001
  2. Published Print: MAY 2001

Abstract

The isolated porcine skin flap is used to determine the rate and extent of absorption of chemicals through skin. This ex vivo model system allows cutaneous toxicology and pharmacology studies to be conducted in viable skin that has a normal structure and intact microvasculature. Porcine skin is also anatomically and physiologically similar to human skin, therefore data from studies using this ex vivo system can in some cases to predict dermatopharmacokinetics and dermotoxicity to test compounds in humans.