UNIT 6.10 Overview of Protein Glutathionylation

  1. Aleksandra Filipovska,
  2. Michael P. Murphy

Published Online: 1 JUN 2006

DOI: 10.1002/0471140856.tx0610s28

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Filipovska, A. and Murphy, M. P. 2006. Overview of Protein Glutathionylation. Current Protocols in Toxicology. 28:6.10:6.10.1–6.10.8.

Author Information

  1. Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom

Publication History

  1. Published Online: 1 JUN 2006
  2. Published Print: MAY 2006


Many proteins contain free thiols that can be modified by the reversible formation of mixed disulfides with glutathione. Protein glutathionylation is of significance for defense against oxidative damage and in redox signaling. Here we outline the mechanisms and possible significance of protein glutathionylation.


  • mitochondria;
  • glutathione;
  • oxidative stress;
  • protein thiols;
  • redox regulation