Unit

UNIT 7.9 Overview of Peroxiredoxins in Oxidant Defense and Redox Regulation

  1. Leslie B. Poole1,
  2. Andrea Hall2,
  3. Kimberly J. Nelson1

Published Online: 1 AUG 2011

DOI: 10.1002/0471140856.tx0709s49

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Poole, L. B., Hall, A. and Nelson, K. J. 2011. Overview of Peroxiredoxins in Oxidant Defense and Redox Regulation. Current Protocols in Toxicology. 49:7.9:7.9.1–7.9.15.

Author Information

  1. 1

    Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina

  2. 2

    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon

Publication History

  1. Published Online: 1 AUG 2011
  2. Published Print: AUG 2011

Abstract

Peroxiredoxins are important hydroperoxide detoxification enzymes, yet have only come to the fore in recent years relative to the other major players in peroxide detoxification, heme-containing catalases and peroxidases and glutathione peroxidases. These cysteine-dependent peroxidases exhibit high reactivity with hydrogen peroxide, organic hydroperoxides, and peroxynitrite and play major roles not only in peroxide defense, but also in regulating peroxide-mediated cell signaling. This overview focuses on important peroxiredoxin features that have emerged over the past several decades with an emphasis on catalytic mechanism, regulation, and biological function. Curr. Protoc. Toxicol. 49:7.9.1-7.9.15. © 2011 by John Wiley & Sons, Inc.

Keywords:

  • peroxidases;
  • antioxidants;
  • antioxidant enzymes;
  • sulfenic acids;
  • hydroperoxides;
  • hydrogen peroxide;
  • thiol peroxidase;
  • Prx;
  • PRDX;
  • redox regulation